Bioinformatics , Proteomics and Immaging Analysis
نویسنده
چکیده
Genomes follow laws resembling celestial orbits. In a recent publication on Nature Scientific Reports[1] two computer scientists (V. Manca and V. Bonnici) discovered strong mathematical regularities in the structure of genomes. These regularities can be expressed in terms of simple laws based on ellipses, hyperbolas and parabolas. But the geometrical forms do not cope with spatial movements, rather they refer to genomic indexes defined by means of information theory[2]. The research started in 2009 at Center of Biomedical Computing of the University of Verona (Italy) directed by one of two authors, with the aim of finding rigorous proofs supporting the intuition that genomes are texts, with a complex internal organization, written during the evolutionary process of living organisms. Along a line of thought, called Infogenomics[3-7], it was argued that these texts contain the deepest secrets that rule the universal mechanisms of life, in all the various and complex phenomena of biological processes. The usual comparison between genomes and computer operating systems is surely significant, because genomes like programs direct procedures activating and regulating the cell processes that realize biological functions. However, this comparison misses a crucial and peculiar aspect of genomes. In fact, these texts are written by themselves during evolution, starting from small initial texts to transform in more complex texts, according to an internal mechanisms that explore enormous genomic spaces, but at same time by maintaining an internal coherence that guarantees the possibility of transmitting their
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